Estimating causal effects of continuous treatments is a common problem in practice, for example, in studying dose-response functions. Classical analyses typically assume that all confounders are fully observed, whereas in real-world applications, unmeasured confounding often persists. In this article, we propose a novel framework for local identification of dose-response functions using instrumental variables, thereby mitigating bias induced by unobserved confounders. We introduce the concept of a uniform regular weighting function and consider covering the treatment space with a finite collection of open sets. On each of these sets, such a weighting function exists, allowing us to identify the dose-response function locally within the corresponding region. For estimation, we develop an augmented inverse probability weighting score for continuous treatments under a debiased machine learning framework with instrumental variables. We further establish the asymptotic properties when the dose-response function is estimated via kernel regression or empirical risk minimization. Finally, we conduct both simulation and empirical studies to assess the finite-sample performance of the proposed methods.

Causal mediation analysis can unpack the black box of causality and is therefore a powerful tool for disentangling causal pathways in biomedical and social sciences, and also for evaluating machine learning fairness. To reduce bias for estimating Natural Direct and Indirect Effects in mediation analysis, we propose a new method called DeepMed that uses deep neural networks (DNNs) to cross-fit the infinite-dimensional nuisance functions in the efficient influence functions. We obtain novel theoretical results that our DeepMed method (1) can achieve semiparametric efficiency bound without imposing sparsity constraints on the DNN architecture and (2) can adapt to certain low dimensional structures of the nuisance functions, significantly advancing the existing literature on DNN-based semiparametric causal inference. Extensive synthetic experiments are conducted to support our findings and also expose the gap between theory and practice. As a proof of concept, we apply DeepMed to analyze two real datasets on machine learning fairness and reach conclusions consistent with previous findings.

The double machine learning (DML) method combines the predictive power of machine learning with statistical estimation to conduct inference about the structural parameter of interest. This paper presents the R package `xtdml`, which implements DML methods for partially linear panel regression models with low-dimensional fixed effects, high-dimensional confounding variables, proposed by Clarke and Polselli (2025). The package provides functionalities to: (a) learn nuisance functions with machine learning algorithms from the `mlr3` ecosystem, (b) handle unobserved individual heterogeneity choosing among first-difference transformation, within-group transformation, and correlated random effects, (c) transform the covariates with min-max normalization and polynomial expansion to improve learning performance. We showcase the use of `xtdml` with both simulated and real longitudinal data.

Estimating causal quantities from observational data is crucial for decision-making in medicine [9, 12, 22, 30, 70]. For example, medical practitioners are interested in estimating the effect of chemotherapy vs. immunotherapy on patient survival from electronic health records to understand the best treatment

Predicting potential outcomes (POs) for patients from observational data is crucial for decision-making in medicine [16].

Causal inference is no exception.

We study a constructive algorithm that approximates Gateaux derivatives for statistical functionals by finite differencing, with a focus on functionals that arise in causal inference. We study the setting where probability distributions are not known a priori but need to be estimated from data. These estimated distributions lead to empirical Gateaux derivatives, and we study the relationships between empirical, numerical, and analytical Gateaux derivatives.

Instrumental variable methods are fundamental to causal inference when treatment assignment is confounded by unobserved variables. In this article, we develop a general nonparametric framework for identification and learning with multi-categorical or continuous instrumental variables. Specifically, we propose an additive instrumental variable framework to identify mean potential outcomes and the average treatment effect with a weighting function. Leveraging semiparametric theory, we derive efficient influence functions and construct consistent, asymptotically normal estimators via debiased machine learning. Extensions to longitudinal data, dynamic treatment regimes, and multiplicative instrumental variables are further developed. We demonstrate the proposed method by employing simulation studies and analyzing real data from the Job Training Partnership Act program.

Estimating heterogeneous treatment effects (HTEs) in time-varying settings is particularly challenging, as the probability of observing certain treatment sequences decreases exponentially with longer prediction horizons. Thus, the observed data contain little support for many plausible treatment sequences, which creates severe overlap problems. Existing meta-learners for the time-varying setting typically assume adequate treatment overlap, and thus suffer from exploding estimation variance when the overlap is low. To address this problem, we introduce a novel overlap-weighted orthogonal (WO) meta-learner for estimating HTEs that targets regions in the observed data with high probability of receiving the interventional treatment sequences. This offers a fully data-driven approach through which our WO-learner can counteract instabilities as in existing meta-learners and thus obtain more reliable HTE estimates. Methodologically, we develop a novel Neyman-orthogonal population risk function that minimizes the overlap-weighted oracle risk. We show that our WO-learner has the favorable property of Neyman-orthogonality, meaning that it is robust against misspecification in the nuisance functions. Further, our WO-learner is fully model-agnostic and can be applied to any machine learning model. Through extensive experiments with both transformer and LSTM backbones, we demonstrate the benefits of our novel WO-learner.